The cellular structures known as proteosomes break down intracellular antigenic proteins so that class I mhc molecules can then present them on the cell surface.
In order for class I mhc molecules to present intracellular antigenic proteins on the cell surface, the cellular structures known as proteosomes must first disassemble them.
All eukaryotic, archaea, and certain bacteria contain proteasomes. Proteasomes are found in the cytoplasm and nucleus of eukaryotes. The proteasome is a cylinder-shaped complex with a central pore formed by a "core" of four stacked rings.
When other cellular proteins are no longer required, a huge protein complex called a proteasome aids in their destruction. Cancer treatment using proteasome inhibitors is currently being researched.
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