"The vast majority of dna damage is caused by man-made chemicals and man-made radiation" is false.
Any modification to DNA that alters its coding properties or normal function in transcription or replication is referred to as DNA damage. DNA damage can impair normal cell replication and increase the rate of apoptosis (programmed cell death, also known as 'cellular senescence'). Damage to genetic material, on the other hand, can result in impaired cellular function, cell loss, or the transformation of healthy cells into cancers. Base substitutions, deletions, and insertions are the three types of DNA mutations.
Endogenous DNA damage sources include hydrolysis, oxidation, alkylation, and base mismatch; exogenous DNA damage sources include ionizing radiation (IR), ultraviolet (UV) radiation, and various chemical agents.
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