Red blood cells usually live for about 120 days before they die and need to be replaced. Sickle cells are fragile — their membranes break apart easily, causing the cells to die after only 10 to 20 days. The result in those with sickle-cell disease is a chronic shortage of red blood cells known as anemia.

Based on this information, why do people with anemia become easily fatigued?

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Answer:

When people have anemia, their body doesn't produce enough red blood cells. They don't get enough oxygen, which makes them feel fatigued and can also cause serious health complications.