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In sickle-cell disease, variation in one gene causes red blood cells to bend, or sickle. This means the sickled cells _____.

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A case study of the effects of mutation: Sickle cell anemia. Sickle cell anemia is a genetic disease with severe symptoms, including pain and anemia. The disease is caused by a mutated version of the gene that helps make hemoglobin — a protein that carries oxygen in red blood cells.

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