is a neurological disease that causes degeneration of lower motor neurons, resulting in flaccid paralysis of muscles and eventual muscle atrophy. Speech sounds weak, hypernasal, monpitched, and articulation is imprecise.
Explanation: Amyotrophic lateral sclerosis (Lou Gehrig disease) targets upper and lower motor neurons (cranial nerves and spinal cord) and results in neuronal cell death and progressive loss of motor function. Patients usually have lower extremity weakness that progresses to complete paralysis over the course of years.
