Which of the following most accurately describes the process that must occur when working with research animals covered by U.S. federal regulations? The research team must obtain IACUC approval for the proposed research procedures prior to starting the work.
The research team can start the project but must receive IACUC approval before its work is published.
The research team can start the project while its protocol is under review by the IACUC but must stop if the IACUC rejects the protocol.
The research team can start the project but must receive IACUC approval before its work is submitted to a journal.

IACUC (Institutional Animal Care and Use Committee) is the group that determines the research facilities keep the accordance of the animal welfare act. The ethical issue must be related to animals.

To proceed any research U.S.federal regulation needs approval of IACUC. The research team requires the approval of IACUC for the research proposal before starting his research on the animals. Researchers must follows the protocols made by IACUC.

Thus, the correct answer is option (1).